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KMID : 0613319980040040179
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Journal of the Korean Bone and Joint Tumor Soceity
1998 Volume.4 No. 4 p.179 ~ p.186
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Solitary Fibrous Tumor of the Soft Tissue
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Kim Kyu-Rae
Ro Jae Y.
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Abstract
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Solitary fibrous tumor(SFT) is a rare but distinctive spindle cell neoplasm which was originally described in the pleura. Subsequently, however, the tumor hart been recognized in many other locations, including body cavities, such as retroperitoneum, mediastinum, scrotum, orbit, nasal cavity, paranasal sinus, within the parenchymal organs, such as lung, limier, kiney, adrenal gland, thyroid gland, and spinal cord, and rarely in the capsular surface of the various organs, such as pericardium, renal capsule, meninges, and periosteum. Recently, cases of SFT haute been reported in somatic soft tissues unrelated to serosal solaces. The tumor has been proposed to be originated from mesenchymal fibroblasts rather than mesothelial or submesothelial origin based on the immunohistochemical, ultrastructural and cell culture studies. We reviewed literatures regarding clinicopathologic, immunohistochemical and ultrastructural features. differential diagnosis, and treatment of SFP. Histologically, the tumor exhibits a haphazard or ´patternless´ arrangement of plump spindle cells in a collagenous background, alternating hypercellular and hypocellular areas, and prominent vascularity resulting in hemangiopericytoma like areas. CD34 CD99 and Bcl-2 immunopositivity are helpful for the differential diagnosis. Complete but conservative surgical excision seems to be the treatment of choice in cases of histologically benign SFT. The tumors showing histologic features of malignancy, such as high cellularity nuclear pleomorphism. high mitotic rate more than 4 in 10 high power fields, and necrosis and hemorrhage behave in a more aggressive manner. Therefore, identification and characterization of the SFT are verb important to avoid misdiagnosis from many other aggressive neoplasms arising in soft tissue, such as fibromatosis, fibrous histiocytoma, fibiosarcoma, synovial sarcoma, dermatofibrosarcoma protuberance, smooth muscle and neural neoplasm, and so called ´hemangiopericytoma´.
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KEYWORD
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Solitary fibrous tumor, Soft tissue, Differential diagnosis, Hemangiopericytoma
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